fetal nasal bone status in iranian women undergoing first-trimester screening for trisomy 21: a review and an observational study.
نویسندگان
چکیده
conclusion the low prevalence of the nb absence in normal fetuses in the present study is compatible with the larger size of the nb in iranian people compared to other communities. meanwhile, the reference range of the nb length in normal iranian fetuses was established so that basic data could be recorded for further studies regarding the absence or presence of the nb in screening for chromosomal abnormalities (down syndrome) within the iranian population. results the nb was absent in 2/767 (0.26%) of the fetuses. the mean length of the nb was 3.6 ± 0.69 mm for the fetuses of 11 - 14 weeks gestational age. the lr value of the absent nb was equal to 250 in the normal fetuses of the iranian population living in the north-west provinces. patients and methods in 767 normal fetuses, the fetal profile was examined by ultrasound for the absence/presence of the nb. the nb length was also measured, and the lr for the nb absence was also determined. objectives the objectives of this study were to determine the nb length and the prevalence of the nb absence as well as calculating the likelihood ratio (lr) for the absence of the nb in normal fetuses of iranian women undergoing first-trimester screening for trisomy 21. background failed visualization of the fetal nasal bone (nb) by ultrasound at 11 - 14 weeks of gestation is strongly associated with chromosomal abnormalities. meanwhile, the incidence of the absent fetal nb in normal fetuses in the first trimester in mothers of different ethnic origins differs significantly. it is, therefore, important to assess ethnic variations in the first-trimester visualization of the fetal nb before introducing this marker into routine screening programs for aneuploidy.
منابع مشابه
Fetal Nasal Bone Status In Iranian Women Undergoing First-Trimester Screening For Trisomy 21: A Review and an Observational Study.
BACKGROUND Failed visualization of the fetal nasal bone (NB) by ultrasound at 11 - 14 weeks of gestation is strongly associated with chromosomal abnormalities. Meanwhile, the incidence of the absent fetal NB in normal fetuses in the first trimester in mothers of different ethnic origins differs significantly. It is, therefore, important to assess ethnic variations in the first-trimester visuali...
متن کاملFirst Trimester Screening for Trisomy 21 by Maternal Age, Nuchal Translucency and Fetal Nasal Bone in Unselected Pregnancies
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Prospective first-trimester screening for trisomy 21 in 30,564 pregnancies.
OBJECTIVE This study was undertaken to evaluate the performance of a 1-stop clinic for first-trimester assessment of risk (OSCAR) for trisomy 21 by a combination of maternal age, fetal nuchal translucency (NT) thickness, and maternal serum-free ss- human chorionic gonadotrophin (hCG) and pregnancy-associated plasma protein-A (PAPP-A). STUDY DESIGN OSCAR was carried out in 30,564 pregnancies a...
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متن کاملScreening of Fetal Chromosome Aneuploidies in the First and Second Trimester of 125,170 Iranian Pregnant Women
BACKGROUND Aneuploidy is one of the main causes of congenital anomalies, mental and physical disabilities, in newborns. The aim of this study was to determine various chromosomal aneuploidies in the first and second trimester screening of pregnant women, in Iran. METHODS A descriptive retrospective study was conducted on 125,170 pregnant women referred to a major referral medical diagnostic l...
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عنوان ژورنال:
iranian journal of radiologyجلد ۱۲، شماره ۴، صفحات ۰-۰
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