fetal nasal bone status in iranian women undergoing first-trimester screening for trisomy 21: a review and an observational study.

نویسندگان

masoud poureisa neurosciences research center (nsrc), department of radiology, radiotherapy and nuclear medicine, tabriz university of medical sciences, tabriz, iran

mohammad hossein daghighi department of radiology, radiotherapy and nuclear medicine, tabriz university of medical sciences, tabriz, iran; department of radiology, radiotherapy and nuclear medicine, tabriz university of medical sciences, tabriz, iran. tel/fax: +98-4133346911

ramin mazaheri khameneh department of surgery and diagnostic imaging, veterinary faculty, urmia university, urmia, iran

sanaz salehi majd imam khomeini general hospital, sardasht, iran

چکیده

conclusion the low prevalence of the nb absence in normal fetuses in the present study is compatible with the larger size of the nb in iranian people compared to other communities. meanwhile, the reference range of the nb length in normal iranian fetuses was established so that basic data could be recorded for further studies regarding the absence or presence of the nb in screening for chromosomal abnormalities (down syndrome) within the iranian population. results the nb was absent in 2/767 (0.26%) of the fetuses. the mean length of the nb was 3.6 ± 0.69 mm for the fetuses of 11 - 14 weeks gestational age. the lr value of the absent nb was equal to 250 in the normal fetuses of the iranian population living in the north-west provinces. patients and methods in 767 normal fetuses, the fetal profile was examined by ultrasound for the absence/presence of the nb. the nb length was also measured, and the lr for the nb absence was also determined. objectives the objectives of this study were to determine the nb length and the prevalence of the nb absence as well as calculating the likelihood ratio (lr) for the absence of the nb in normal fetuses of iranian women undergoing first-trimester screening for trisomy 21. background failed visualization of the fetal nasal bone (nb) by ultrasound at 11 - 14 weeks of gestation is strongly associated with chromosomal abnormalities. meanwhile, the incidence of the absent fetal nb in normal fetuses in the first trimester in mothers of different ethnic origins differs significantly. it is, therefore, important to assess ethnic variations in the first-trimester visualization of the fetal nb before introducing this marker into routine screening programs for aneuploidy.

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Fetal Nasal Bone Status In Iranian Women Undergoing First-Trimester Screening For Trisomy 21: A Review and an Observational Study.

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عنوان ژورنال:
iranian journal of radiology

جلد ۱۲، شماره ۴، صفحات ۰-۰

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